FIGURE

Fig. 1

ID

ZDB-FIG-220819-17

Publication

Willekers et al., 2022 - The centriolar satellite protein Cfap53 facilitates formation of the zygotic microtubule organizing center in the zebrafish embryo

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Fig. 1

MPcfap53^−/− embryos arrest and display aberrant nuclear morphology. (A,B) Time series of maternal and paternal (MP)cfap53^−/− embryos from 45 mpf up to 4 hpf. Although a small fraction of the MPcfap53^−/− embryos displayed normal development (A, n=15), most embryos arrested at the one-cell stage (B, n=52). (C,D) Confocal images of wild-type (C) and MPcfap53^−/− (D) embryos at indicated stages of development stained with DAPI to visualize nuclei, indicating that aberrant nuclear morphology starts to form at 30 mpf. Results were obtained from two different cfap53^−/− pairs. Asterisks indicate polar bodies. Gender symbols indicate a male or female pro-nucleus. Scale bars: 100 μm in A,B; 20 μm in C,D. Schematics of embryonic development are adapted, with permission, from Kimmel et al. (1995).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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