ZFIN Image: Willekers et al., 2022, Fig. 1

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Figure Caption

Fig. 1

MPcfap53^?/? embryos arrest and display aberrant nuclear morphology. (A,B) Time series of maternal and paternal (MP)cfap53^?/? embryos from 45?mpf up to 4?hpf. Although a small fraction of the MPcfap53^?/? embryos displayed normal development (A, n=15), most embryos arrested at the one-cell stage (B, n=52). (C,D) Confocal images of wild-type (C) and MPcfap53^?/? (D) embryos at indicated stages of development stained with DAPI to visualize nuclei, indicating that aberrant nuclear morphology starts to form at 30?mpf. Results were obtained from two different cfap53^?/? pairs. Asterisks indicate polar bodies. Gender symbols indicate a male or female pro-nucleus. Scale bars: 100??m in A,B; 20??m in C,D. Schematics of embryonic development are adapted, with permission, from Kimmel et al. (1995).

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