FIGURE

Fig. 5

ID

ZDB-FIG-220810-58

Publication

Fu et al., 2022 - N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway

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Fig. 5

Fig. 5. Wnt/?-catenin signaling mediates MNU-induced abnormal angiogenesis. A. Representative images of ISV and hindbrain vessels from control group, MNU-treated group, BIO-treated group, BIO plus MNU-treated group, CCT-treated group and CCT plus MNU-treated group at 48 hpf. White arrows point to ectopic ISV branches. Red arrows point to the central artery (CA). BIO, (2'Z,3'E)??6-bromoindirubin-3'-oxime; CCT, CCT036477. Scale bar, 50?�m. B. Quantitative analysis of ectopic intersegmental vessel (ISV) branches in control group, MNU-treated group, BIO-treated group, BIO plus MNU-treated group, CCT-treated group and CCT plus MNU-treated group at 48 hpf. Data were obtained from three independent experiments and are shown as the mean �?SEM. *?**P?<?0.001, *?*?P?<?0.01, *?P?<?0.05. C. Quantitative analysis of gsk-3? and ?-catenin expression of the control group and MNU-treated group by RT-qPCR. The data are presented as the mean �?SEM. *?**?*?P?<?0.0001, *?P?<?0.05.

Expression Data

Genes:	ctnnb1 gsk3ba
Fish:	s843Tg/s843Tg
Condition:	chemical treatment by environment: N-methyl-N-nitrosourea
Anatomical Term:	whole organism
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg/s843Tg
Conditions:	chemical treatment by environment: N-methyl-N-nitrosourea chemical treatment by environment: N-methyl-N-nitrosourea chemical treatment by environment: N-methyl-N-nitrosourea chemical treatment by environment: Wnt signalling activator chemical treatment by environment: Wnt signalling inhibitor
Observed In:	intersegmental vessel branching involved in blood vessel morphogenesis mid cerebral vein branching involved in blood vessel morphogenesis whole organism
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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