Fig. 5
- ID
- ZDB-FIG-220727-47
- Publication
- Jeong et al., 2022 - Therapeutic Potential of CKD-504, a Novel Selective Histone Deacetylase 6 Inhibitor, in a Zebrafish Model of Neuromuscular Junction Disorders
- Other Figures
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Impaired NMJs can be restored by inhibiting HDAC6.
(A) Lateral view images after staining with anti-SV2 and α-BTX of a whole-mounted zebrafish injected with control, gars MOs, or treated with tubastatin A (TubA). The merged images are magnified from the images in the rectangular regions. Scale bars = 50 μm. (B) Comparison of fluorescence intensity (green, presynapse; red, postsynapse) among MO-injected and TubA-treated zebrafish embryos. (C-E) Comparison of presynapse (C), postsynapse (D), and NMJ (E) signal ratios within the ROI among zebrafish embryos injected with control MOs (n = 24), gars MOs (n = 17), and gars MOs with TubA (n = 21). Statistical significance was assessed using one-way ANOVA followed by Tukey’s post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001. ns, non-significant. (F and G) Comparison of NMJ innervation in the presynaptic (F) and postsynaptic (G) areas among zebrafish embryos injected with control MOs (n = 23), gars MOs (n = 29), and gars MOs with a TubA treatment (n = 36). Statistical significance was determined using one-way ANOVA followed by Tukey’s post hoc test. ***P < 0.001. ns, non-significant. |
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| Anatomical Terms: | |
| Stage: | Protruding-mouth |
| Fish: | |
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| Condition: | |
| Knockdown Reagent: | |
| Observed In: | |
| Stage: | Protruding-mouth |