Fig. 6

The loss of Elmo1 led to altered blood glucose levels in adult zebrafish. (A) Whole body glucose levels were not changed in elmo1 ^−/− compared to elmo1 ^+/+ at 120 hpf. n = 8 samples per group, each containing 20 zebrafish larvae. (B) Fasting blood glucose levels were decreased in adult elmo1 ^−/− . (C) Postprandial blood glucose levels were increased in adult elmo1 ^−/− . (D) Whole body glucose levels were not changed in elmo2 ^−/− compared to elmo2 ^+/+ at 120 hpf. n = 6 samples per group, each containing 20 zebrafish larvae. (E,F) Fasting and postprandial blood glucose levels were unaltered in adult elmo2 ^−/− . (G) Whole body glucose levels were not changed in elmo3 ^−/− compared to elmo3 ^+/+ at 120 hpf. n = 9 samples per group, each containing 20 zebrafish larvae. (H,I) Fasting and postprandial blood glucose levels were unaltered in adult elmo3 ^−/− . Blood glucose was obtained from animals of 7–15 mpf. Statistical analysis was done with t-test and Mann-Whitney test. *p < 0.05, **p < 0.01. ns, not significant; hpf, hours post fertilization; mpf, months post fertilization.