FIGURE

Fig. 1

ID

ZDB-FIG-220725-26

Publication

Osorio-Méndez et al., 2022 - Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins

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Fig. 1

The temca mutants display temperature-sensitive locomotion and fin-regeneration defects. (A) Swimming behavior of control (wild-type siblings) and temca at 26 °C (Left) and 33 °C (Right). (Bottom) Representative 1-min swimming trajectories of individual fish. Color code indicates video frame, and the distance between dots indicates speed. (B and C) Quantification of 3-min swimming behavior of control and temca mutants at 26 °C (Left) and 33 °C (Right). (B) Average distance traveled (n = 5). (C) Duration of immobility at the bottom of swimming tanks (n = 5). (D) Representative whole-mount images of control and temca 7 dpa fins at 26 °C (Left) and 33 °C (Right). White arrows indicate impaired fin regenerates of temca mutants. Red arrows indicate amputation plane. (E) Quantification of fin-regenerate lengths at 7 dpa at 26 °C (n = 62 and 39 for control and temca, respectively) and 33 °C (n = 51 and 43 for control and temca, respectively). Data are presented as mean ± SD. Student’s unpaired two-tailed t test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT scn8ab^pd291/pd291
Conditions:	amputation: caudal fin, heat exposure heat exposure
Observed In:	caudal fin caudal fin fin regeneration caudal fin principal ray swimming
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA