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Publication: Osorio-Méndez et al., 2022 - Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins
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Fig. 1

The temca mutants display temperature-sensitive locomotion and fin-regeneration defects. (A) Swimming behavior of control (wild-type siblings) and temca at 26 °C (Left) and 33 °C (Right). (Bottom) Representative 1-min swimming trajectories of individual fish. Color code indicates video frame, and the distance between dots indicates speed. (B and C) Quantification of 3-min swimming behavior of control and temca mutants at 26 °C (Left) and 33 °C (Right). (B) Average distance traveled (n = 5). (C) Duration of immobility at the bottom of swimming tanks (n = 5). (D) Representative whole-mount images of control and temca 7 dpa fins at 26 °C (Left) and 33 °C (Right). White arrows indicate impaired fin regenerates of temca mutants. Red arrows indicate amputation plane. (E) Quantification of fin-regenerate lengths at 7 dpa at 26 °C (n = 62 and 39 for control and temca, respectively) and 33 °C (n = 51 and 43 for control and temca, respectively). Data are presented as mean ± SD. Student’s unpaired two-tailed t test.

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