FIGURE

Fig. 2

ID

ZDB-FIG-220627-13

Publication

Lee et al., 2022 - FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer's disease

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Fig. 2

Expression of fmnl2a in zebrafish brain overlaps with astroglia. a Singe cell sequencing tSNE plots for her4.1 and fmnl2a in adult zebrafish telencephalon. b Amyloid toxicity assay and bulk RNA sequencing results for fmnl2a gene expression. c, d Double immunohistochemical staining (dIHCs) for her4.1: GFP (astroglia) and Fmnl2 in control (c) and amyloid-injected (d) brains with DAPI counterstain. c′, d′ individual fluorescent channels for Fmnl2. e, f Higher magnification image showing overlapping Fmnl2 and her4.1-driven GFP. g, h Double channel colocalization analyses of e and f. R Pearson correlation coefficient, ρ Spearmann’s rank coefficient. Scale bars as indicated

Expression Data

Genes:	EGFP fmnl2a her4.1
Antibody:	Ab1-fmnl2
Fish:	y83Tg (AB)
Condition:	chemical treatment by injection: amyloid-beta polypeptide 42
Anatomical Term:	brain astrocyte
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y83Tg (AB)
Condition:	chemical treatment by injection: amyloid-beta polypeptide 42
Observed In:	brain astrocyte
Stage:	Adult

Phenotype Detail

Acknowledgments

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