FIGURE

Fig. 3

ID

ZDB-FIG-220607-5

Publication

Tang et al., 2022 - Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling

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Fig. 3

Dnmt1 is required for neuromast deposition in zebrafish posterior lateral line. A-B, At 48 hpf, the gross morphology of wild-type embryos and Dnmt1-deficient embryos. D-E, Reduced number of neuromasts and extended distance between neuromasts are found in the staining of eya1 in lateral line neuromasts when compared the controls (D) with the Dnmt1 morphants (E). G-H, The transgenic zebrafish line cldnb:lynGFP confirms the results observed in WISH. (C, F, I) Successful rescue of morphology, eya1 staining and green fluorescence labelled neuromasts are achieved in mRNA and MO co-injection groups. The black arrowheads in D-F, and the white arrowheads in G-I both mark the PLL neuromasts. Scale bars mark the 200 μm scale. (J) Statistic analysis of the number of posterior LL neuromasts at 48 hpf in controls (n = 117), Dnmt1-deficient embryos (n = 159) and Dnmt1-MO + mRNA members (n = 159). ****p < 0.0001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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