FIGURE

Fig. 1

ID

ZDB-FIG-220530-1

Publication

García-Castillo et al., 2021 - Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis

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Fig. 1

Zebrafish terc controls the expression of promyelopoietic genes in vivo. (A) Workflow of the generation of the terc−/− (terc KO) zebrafish line. (B) Workflow of the generation of the Tg(drl::terc) zebrafish line. (C–F) Expression of the indicated genes in the CHT of wild-type (wt), Tg(drl::terc), and terc KO fish larvae at 2 dpf. Data are representative results of three independent experiments; n = at least 20 larvae per group. (G) Neutrophil counts in the CHT of mpx::GFP larvae (neutrophils labeled by GFP) at 3 dpf. Data are the average of two independent experiments; n = 21 for wt and Tg(drl::terc), and n = 19 for terc KO. Data values shown are fold change over the value of wt sample in C, D, and E. All data are mean + SEM. *P < 0.05, **P < 0.01, and ***P < 0.001 for one-way ANOVA plus Bonferroni posttest.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA