Gene
csf3b
- ID
- ZDB-GENE-141212-221
- Name
- colony stimulating factor 3 (granulocyte) b
- Symbol
- csf3b Nomenclature History
- Previous Names
-
- Gcsf (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Acts upstream of or within hemopoiesis and neutrophil chemotaxis. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; heart; immune system; myeloid cell; and testis. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Galdames et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-csf3b | N/A | (3) |
| MO2-csf3b | N/A | Galdames et al., 2014 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core | GCSF/MGF |
|---|---|---|---|---|
| UniProtKB:A0A8M2BL23 | InterPro | 271 | ||
| UniProtKB:B5L332 | InterPro | 185 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-205C8 | ZFIN Curated Data |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143754 (1) | 871 nt | ||
| Genomic | GenBank:FP017234 (1) | 35814 nt | ||
| Polypeptide | UniProtKB:A0A8M2BL23 (1) | 271 aa |
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Liao, X., Lan, Y., Wang, W., Zhang, J., Shao, R., Yin, Z., Gudmundsson, G.H., Bergman, P., Mai, K., Ai, Q., Wan, M. (2023) Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens. Gut microbes. 15:21875752187575
- Martínez-Balsalobre, E., García-Castillo, J., García-Moreno, D., Naranjo-Sánchez, E., Fernández-Lajarín, M., Blasco, M.A., Alcaraz-Pérez, F., Mulero, V., Cayuela, M.L. (2023) Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes. Nature communications. 14:59125912
- Sobah, M.L., Scott, A.C., Laird, M., Koole, C., Liongue, C., Ward, A.C. (2023) Socs3b regulates the development and function of innate immune cells in zebrafish. Frontiers in immunology. 14:11197271119727
- Maradonna, F., Fontana, C.M., Sella, F., Giommi, C., Facchinello, N., Rampazzo, C., Caichiolo, M., Hoseinifar, S.H., Dalla Valle, L., Van Doan, H., Carnevali, O. (2022) A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer. Cell Death & Disease. 13:10691069
- Meier, A.B., Basheer, F., Sertori, R., Laird, M., Liongue, C., Ward, A.C. (2022) Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish. Frontiers in bioscience (Landmark edition). 27:110
- Solman, M., Blokzijl-Franke, S., Piques, F., Yan, C., Yang, Q., Strullu, M., Kamel, S.M., Ak, P., Bakkers, J., Langenau, D.M., Cave, H., den Hertog, J. (2022) Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects. eLIFE. 11:
- Cabezas-Sainz, P., Coppel, C., Pensado-López, A., Fernandez, P., Muinelo-Romay, L., López-López, R., Rubiolo, J.A., Sánchez, L. (2021) Morphological Abnormalities and Gene Expression Changes Caused by High Incubation Temperatures in Zebrafish Xenografts with Human Cancer Cells. Genes. 12(1):
1 - 10 of 26
Show