FIGURE

FIGURE 5

ID

ZDB-FIG-220515-28

Publication

Hason et al., 2022 - Bioluminescent Zebrafish Transplantation Model for Drug Discovery

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FIGURE 5

Targeted signaling pathways as predicted from in vivo kinase inhibitor screen. For simplicity, we show the predicted human proteins in this figure without the zebrafish paralogs. Proteins, that were targeted by our kinase inhibitor set are depicted in color, non-targeted ones are white. Selected inhibitors with a potent new function are depicted in the schemes as well. Signaling pathways in (A) BRAF^V600E mutant melanoma cells and in (B) cells of chronic myelogenous leukemia (CML) with BCR-ABL translocation. Figure created in bioRENDER.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol