FIGURE 4

Kinase inhibitor active in transplanted leukemia K562 cells. (A) Inhibitors that targeted the RAS and p38 MAPK pathways and significantly inhibited leukemia cell growth in vivo. (B) Inhibitors that targeted cell cycle and cell migration related proteins and significantly inhibited leukemia cell growth in vivo. (A,B) Statistical significance was determined by Mann-Whitney test. *p < 0.04, **p < 0.002, ***p < 0.001. Luminescence measured in vivo in single embryos is represented by a single dot in dot plots. All experiments were done in 2–3 repeats. (C) List of all the inhibitors from A-B with their predicted main protein targets in human K562 cells. The last column with red bars on the right represents the average expression of individual target genes in human cells which was extracted from a publicly available RNA-sequencing dataset. Inhibitors with a potent new function in leukemia are labeled with a red asterisk.