FIGURE

Fig. 3

ID

ZDB-FIG-220509-13

Publication

Amanda et al., 2022 - IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

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Fig. 3

Identification of multiple cell populations derived from different stages of lymphocyte differentiation.

A Schematic diagram of the sample preparation for scRNA-seq analysis. B UMAP plot showing T and B lymphocytes from one control zebrafish. We first selected T and B-cell clusters and then performed a subclustering analysis. Six populations were then defined based on marker gene expression. C UMAP plots showing aggregated cells from 20 independent zebrafish. Six populations were annotated using the same criteria used in (B). D Bar charts showing the percentage of different cell populations in each sample. Source data are provided as a Source Data file.

Expression Data

Genes:	gzmk sox4a trgc
Fish:	ns106Tg/ns106Tg tp53^zdf1/+; ns106Tg/ns106Tg
Anatomical Terms:	gamma-delta T cell neoplasm T cell neoplasm
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ns106Tg/ns106Tg tp53^zdf1/+; ns106Tg/ns106Tg
Observed In:	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment gamma-delta T cell neoplasm pro-T cell T cell neoplasm whole organism precursor T-cell neoplasms
Stage:	Adult

Phenotype Detail

Acknowledgments

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