FIGURE

Figure 2

ID

ZDB-FIG-220411-2

Publication

Sheng et al., 2022 - MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development

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Figure 2

miR-22a regulates ISV tip cell behaviour. (a,b) Still images from in vivo time-lapse imaging analysis of Tg(kdrl:EGFP) embryos with HD detection setting. Time stages (hpf) are noted at the left side. The yellow arrows indicate the upward tip cells in the control groups. The blue arrows indicate the lateral tip cells. The red arrows indicate the downward tip cells. The rectangle box in dash line indicates the multidirectional filopodial extensions in the miR-22a deficiency embryos. (c,d) Diagrams of ISV morphology in control and miR-22a MO-injected embryos.

Expression Data

Gene:	EGFP
Fish:	s843Tg s843Tg + MO1-dre-mir-22a
Knockdown Reagent:	MO1-dre-mir-22a
Anatomical Terms:	CaP motoneuron axon intersegmental vessel blood vessel endothelial cell MiP motor neuron axon RoP motor neuron axon
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg + MO1-dre-mir-22a
Knockdown Reagent:	MO1-dre-mir-22a
Observed In:	CaP motoneuron axon extension involved in axon guidance intersegmental vessel cell migration involved in sprouting angiogenesis
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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