FIGURE

Fig. 1

ID

ZDB-FIG-220409-1

Publication

Monroe et al., 2022 - Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish

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Fig. 1

Induction of transgenes causes rapid oncogenic transformation of normal zebrafish liver cells into HCC cells. Representative histological cross sections of 3-month post-fertilization (mpf) DOX-treated zebrafish liver tissue from 1.5 to 7.5 dpt. Images were taken at 40× magnification. A x−m−, non-transgenic control; B x+m−, xmrk oncogene expression; C x−m+, Myc oncogene expression; D x+m+, xmrk and Myc oncogene expression. Key: black arrows, apoptotic cells; black boxes, syncytial cells with multiple nuclei indicating abnormal mitosis. Error bars = 20 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gz26Tg/gz26Tg gz25Tg/gz25Tg gz25Tg/gz25Tg; gz26Tg/gz26Tg
Condition:	chemical treatment by environment: doxycycline
Observed In:	liver hepatocellular carcinoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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