FIGURE

Figure 7

ID
ZDB-FIG-220402-43
Publication
Jadhao et al., 2022 - Endoglin Modulates TGFβR2 Induced VEGF and Proinflammatory Cytokine Axis Mediated Angiogenesis in Prolonged DEHP-Exposed Breast Cancer Cells
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Figure 7

Schematic representation of prolonged DEHP exposure-induced angiogenesis potential in breast cancer cells. Prolonged DEHP exposure at physiological concentrations upregulate the expression of endoglin (ENG). Endoglin overexpression activates TGFβ and MAPK/p38 signaling-mediated production of VEGF; inflammatory cytokines IL1α, IL1β, IL6, IL8; and GMCSF, contributing to enhanced DEHP-induced angiogenesis potential in breast cancer cells. shRNA mediated ENG knockdown reversed ENG induced angiogenesis through downregulation of TGFβ and MAPK/p38 signaling along with reduced expression of inflammatory cytokines IL1α, IL1β, IL6, IL8; and GMCSF.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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