FIGURE

Figure 1

ID

ZDB-FIG-220402-26

Publication

Kulkarni et al., 2022 - A Novel 2-Hit Zebrafish Model to Study Early Pathogenesis of Non-Alcoholic Fatty Liver Disease

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Figure 1

High fat diet treatment. (A) The schematic for high-fat diet feedings of the zebrafish larvae. (B,C) BODIPY labeling of unfed (B) and 5% High-fat Diet (HFD) fed larvae (C). There is minimal accumulation of lipid droplets in the liver of unfed larvae (outlined by dashed white line), while HFD treatment resulted in significant accumulation of lipid droplets in hepatocytes. (D) The larval mRNA level of tnfa only is significantly increased in response to HFD. Expression analyses were performed on whole larvae. Statistical analyses by students t-test, n = 4–5 clutches with at least 15 embryos per clutch. ns—not significant,* p < 0.05.

Expression Data

Gene:	tnfa
Fish:	WT
Condition:	high fat
Anatomical Term:	whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	high fat
Observed In:	hepatocyte lipid droplet whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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