FIGURE

Fig 4

ID

ZDB-FIG-220319-53

Publication

Liu et al., 2022 - Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration

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Fig 4

Distribution of the rods and expression of the rod opsin in the WT and <italic toggle='yes'>nrl</italic>-KO retinas from 1 mpf to 3 mpf.

(A) The Tg(rho:EGFP) transgenic line was used to label rods with EGFP. Representative images of flattened whole-mount retinas from WT and nrl-KO zebrafish at 1 mpf, 2 mpf, and 3 mpf are shown. The dashed lines indicate the edges of the retinas. Scale bars: 200 μm. (B) EGFP-labeled rods were observed on the retinal sections from WT and nrl-KO Tg(rho:EGFP) transgenic zebrafish at 1 mpf. The overall views are shown in the upper panel. The regions nearby the ciliary marginal zone (labeled with boxes) showed no or little fluorescence signal of rods. Enlarged images of the dorsal retinal regions are shown in the lower panel. ROS, rod outer segment; CN, cone nuclear layer; RN, rod nuclear layer; INL, inner nuclear layer; GCL: ganglion cell layer. Scale bars: 50 μm.

Expression Data

Gene:	EGFP
Fish:	kj2Tg nrl^hzu16/hzu16; kj2Tg
Anatomical Term:	retinal rod cell
Stage Range:	Days 30-44 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nrl^hzu16/hzu16; kj2Tg
Observed In:	ciliary marginal zone retinal rod cell retinal outer nuclear layer retinal rod cell retinal rod cell
Stage Range:	Days 30-44 to Adult

Phenotype Detail

Acknowledgments

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