FIGURE

Fig. 5

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ZDB-FIG-220304-36

Publication

Wyatt et al., 2021 - Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail

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Fig. 5

Collagen remodelling occurs during fin development, as does Mmp2 activation. Collagen is a constitutive component of developing fins (A), found perichordally (I) and along the developing fin rays (II). Denatured collagen is found along the notochord sheath (I), as well as, to a lesser extent, in the interior of the notochord, evident most strongly at the anterior tip (III). Denatured collagen is also found between where the layers of actinotrichia would be found, on podosome-like cell processes (IV). Activation of EMMA-Mmp2 (E,F) is not strongly associated to the notochord sheath, but instead is concentrated in the neural tube (V) and in a patchwork pattern of epithelial cells (VI) at these stages. Patterns are representative of at least 10 embryos imaged for each assay.

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Reprinted from Developmental Biology, 477, Wyatt, R.A., Crawford, B.D., Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail, 155-163, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.