FIGURE

Fig. 1

ID

ZDB-FIG-220304-32

Publication

Wyatt et al., 2021 - Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail

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Fig. 1

Sequences surrounding proteolytic cut sites are conserved in the propeptide of gelatinase A orthologues. Blue arrow indicates the N-terminus created by removal of the secretory signal during translation, green indicates the N-terminus of the intermediate created by MT1-MMP and red indicates the active MMP-2 terminus thought to be an autocatalytic cleavage site (Strongin et al., 1993). Grey shading indicates the novel cut site detectable by thrombin/factor Xa when mutagenesis (?, ?) blocks the recognition of the other two cut sites (Koo et al., 2009). Asterisk marks the cysteine of the cysteine switch. Sequence coordinates marked are alignment coordinates, not protein coordinates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 477, Wyatt, R.A., Crawford, B.D., Post-translational activation of Mmp2 correlates with patterns of active collagen degradation during the development of the zebrafish tail, 155-163, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.