FIGURE

FIGURE 7

ID
ZDB-FIG-220303-21
Publication
Di Schiavi et al., 2022 - Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development
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FIGURE 7

Potential interaction between the modeled human olfactorin structures with the resolved FGFR1-FGF2 complex (PDB code: 1FQ9) and its comparison with anosmin-1. As evidenced (red circles) WAP domains of olfactorin and anosmin-1 interact with the D2 domain of FGFR1 by assuming comparable arrangements. Greater differences are seen in the pose of the FNIII.1 domain; however, in both complexes it appears to conveniently approach the D2 domain of FGFR1. As shown in the left panel, the WAP-FGFR1 interactions appear to be mostly stabilized by ionic contacts.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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