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FIGURE 7
Potential interaction between the modeled human olfactorin structures with the resolved FGFR1-FGF2 complex (PDB code: 1FQ9) and its comparison with anosmin-1. As evidenced (red circles) WAP domains of olfactorin and anosmin-1 interact with the D2 domain of FGFR1 by assuming comparable arrangements. Greater differences are seen in the pose of the FNIII.1 domain; however, in both complexes it appears to conveniently approach the D2 domain of FGFR1. As shown in the left panel, the WAP-FGFR1 interactions appear to be mostly stabilized by ionic contacts.
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Full text @ Front Cell Dev Biol