FIGURE

Fig. 2

ID

ZDB-FIG-220211-9

Publication

Wohlfart et al., 2022 - Accumulation of acetaldehyde in aldh2.1^-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism

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Fig. 2

Loss of aldh2.1 led to increased angiogenesis in the retinal vasculature of zebrafish larvae and adults. A: Representative confocal images of hyaloid vasculature in zebrafish larvae at 120 hpf displayed increased branching. Red scale bar: 20 μm, red arrows: branch points as counted for quantification. B: Representative confocal images of adult zebrafish retinae showed increased angiogenesis. White Scale Bar: 350 μm, red rectangle: high-density subdivision, blue rectangle 350 μm square, red arrows: branch points as counted for quantification. C: Quantification of larval hyaloid vasculature showed increased numbers of branch points in aldh2.1^−/− mutants, n = 22–24 eyes per group. D: Quantification of retinal vasculature showed increased numbers of branch points in aldh2.1^−/− adults, n = 16–17 350 μm squares per group, statistical analysis was done via Student's - test, *p < 0.05, ***p < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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