FIGURE

Figure 6

ID
ZDB-FIG-220131-364
Publication
Barth et al., 2021 - Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging
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Figure 6

Matching of our CR-related DEGs evidenced to be regulated with aging with a curated human CR network. The core clock network (CCN; inner ring) is comprised of a positive (orange) and negative (purple) branch of core clock regulators and has been expanded to an extended core clock network (ECCN; middle ring) as determined by chronobiological meta-analyses in humans [84]. The majority of CR-related genes identified in the present study overlaps (represented in bold) with the human CCN (100% overlap) and ECCN (65.5% overlap). The ECCN was complemented by 13 CR-related genes defined by our aging-related interspecies approach (outer ring), two of which overlapped with newly designated CR genes (bold in outer ring [84]). By mapping to a curated biomedical aging database [101], 85% of the presented interspecies (dark blue background) or human (light blue background) CR-related genes were identified to be aging-associated. The remaining factors (white background) have not yet been annotated to aging but might represent new candidates. *, curated CR-related genes without age-related differential expression within the interspecies comparison.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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