PUBLICATION
Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging
- Authors
- Barth, E., Srivastava, A., Wengerodt, D., Stojiljkovic, M., Axer, H., Witte, O.W., Kretz, A., Marz, M.
- ID
- ZDB-PUB-211221-27
- Date
- 2021
- Source
- Aging 13(24): 25694-25716 (Journal)
- Registered Authors
- Keywords
- RNA-Seq, aging, circadian clock system, circadian rhythm, inter-species comparison, longevity
- MeSH Terms
-
- Aged
- Aging/genetics*
- Aging/physiology
- Animals
- Circadian Clocks/genetics*
- Circadian Rhythm/genetics*
- Cross-Sectional Studies
- Humans
- Longevity*
- Mice
- Transcriptome*
- Zebrafish/genetics
- PubMed
- 34923482 Full text @ Aging (Albany NY)
Citation
Barth, E., Srivastava, A., Wengerodt, D., Stojiljkovic, M., Axer, H., Witte, O.W., Kretz, A., Marz, M. (2021) Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging. Aging. 13(24):25694-25716.
Abstract
The circadian clock system influences the biology of life by establishing circadian rhythms in organisms, tissues, and cells, thus regulating essential biological processes based on the day/night cycle. Circadian rhythms change over a lifetime due to maturation and aging, and disturbances in the control of the circadian system are associated with several age-related pathologies. However, the impact of chronobiology and the circadian system on healthy organ and tissue aging remains largely unknown. Whether aging-related changes of the circadian system's regulation follow a conserved pattern across different species and tissues, hence representing a common driving force of aging, is unclear. Based on a cross-sectional transcriptome analysis covering 329 RNA-Seq libraries, we provide indications that the circadian system is subjected to aging-related gene alterations shared between evolutionarily distinct species, such as Homo sapiens, Mus musculus, Danio rerio, and Nothobranchius furzeri. We discovered differentially expressed genes by comparing tissue-specific transcriptional profiles of mature, aged, and old-age individuals and report on six genes (per2, dec2, cirp, klf10, nfil3, and dbp) of the circadian system, which show conserved aging-related expression patterns in four organs of the species examined. Our results illustrate how the circadian system and aging might influence each other in various tissues over a long lifespan and conceptually complement previous studies tracking short-term diurnal and nocturnal gene expression oscillations.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping