FIGURE
Fig. 4
- ID
- ZDB-FIG-220131-154
- Publication
- Huang et al., 2022 - RNF12 is regulated by AKT phosphorylation and promotes TGF-β driven breast cancer metastasis
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Fig. 4
AKT activation promotes the nucleus localization of RNF12.
A Immunofluorescence and 4, 6-diamidino-2-phenylindole (DAPI) staining of HeLa cells stably transfected with RNF12 WT, S215A, S347A/T349A, or S215A/S347A plasmids. Left panel: Number of cells (A) were analyzed according to the following subgroups: cytoplasm, nuclear, or at both locations (both). B Immunofluorescence and DAPI staining of MDA-MB-231 cells treated with IGF-1 (200 ng/mL) and MK2206 (5 μM). C Immunofluorescence and DAPI staining of HeLa cells transfected with Flag-RNF12 and GFP-SMAD7, treated with DMSO or MK2206 (5 μM) for 8 h. D Western blotting experiments relevant with C. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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