FIGURE

Figure 3

ID

ZDB-FIG-220104-78

Publication

Shiau et al., 2021 - FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer

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Figure 3

VEGFR2 is regulated through gene expression of FAK in TNBC cells. (A) Knockdown of FAK decreased VEGFR2 gene expression in MDA-MB-231 and MDA-MB-468 cells. (B) VEGFR2 gene expression decreased in two stable knockdown FAK clones. (C) The different gene expressions in shLuci and two shFAK MDA-MB-231 cells from RNA sequencing displayed as a volcano plot. Red marks represent upregulated genes and blue marks represent downregulated genes. (D) Heatmap shows that several angiogenic related gene expressions, such as PTK2, KDR, TGF-β1, HIF-1α, etc., were reduced significantly in shFAK TNBC cells. (E) Knockdown of VEGFR2 expression could not affect FAK gene expression in MDA-MB-231 and MDA-MB-468 cells. Data from three independent experiments were used for statistical analysis and *: p < 0.05.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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