ZFIN Image: Shiau et al., 2021, Figure 3

Image

Figure Caption

Figure 3

VEGFR2 is regulated through gene expression of FAK in TNBC cells. (A) Knockdown of FAK decreased VEGFR2 gene expression in MDA-MB-231 and MDA-MB-468 cells. (B) VEGFR2 gene expression decreased in two stable knockdown FAK clones. (C) The different gene expressions in shLuci and two shFAK MDA-MB-231 cells from RNA sequencing displayed as a volcano plot. Red marks represent upregulated genes and blue marks represent downregulated genes. (D) Heatmap shows that several angiogenic related gene expressions, such as PTK2, KDR, TGF-β1, HIF-1α, etc., were reduced significantly in shFAK TNBC cells. (E) Knockdown of VEGFR2 expression could not affect FAK gene expression in MDA-MB-231 and MDA-MB-468 cells. Data from three independent experiments were used for statistical analysis and *: p < 0.05.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biomedicines