FIGURE

Fig 4

ID

ZDB-FIG-211201-4

Publication

Gibson et al., 2021 - Commensal bacteria augment Staphylococcus aureus infection by inactivation of phagocyte-derived reactive oxygen species

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Fig 4

S. aureus strains susceptible to ROS are augmented in vitro and in vivo.

A Reactive oxygen species generated in the oxidative burst, highlighting where KatA and AhpC action occurs B Following hydrogen peroxide exposure, percentage survival of S. aureus katAahpC mutants alone (5x10⁴ CFU/mL), or with live M. luteus (5x10⁶ CFU/mL), heat-killed M. luteus (equivalent of 5x10⁶ CFU/mL) or ROS killed M. luteus (equivalent of 5x10⁶ CFU/mL), (n = 3, error bars show mean +/- SD, one-way ANOVA test with Tukey?s post hoc test), ***p<0.0002; ****p<0.0001 C Co-injection of low dose S. aureus katAahpC (1x10⁶ CFU) with heat-killed M. luteus (equivalent of 1x10⁸ CFU) into mice: liver CFU, enumerated at 3 days post-infection (n = 5 per group, median value shown, two-tailed Mann-Whitney test), *p<0.05 D Co-injection of low dose S. aureus (SA 2x10⁵ CFU) with M. luteus PGN (ML PGN 500 ?g) into wild-type (WT) control mice or MPO^-/- mice: liver CFU, enumerated at 3 days post-infection (n = 9 per group, median value shown, individual two-tailed Mann-Whitney tests), *p<0.05, **p<0.002, ***p<0.0006.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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