Figure 3
- ID
- ZDB-FIG-211103-7
- Publication
- Lee et al., 2021 - Neuroprotective Effects of Estradiol plus Lithium Chloride via Anti-Apoptosis and Neurogenesis Pathway in In Vitro and In Vivo Parkinson's Disease Models
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Effect of lithium chloride and E2 on 6-OHDA-induced downregulation of phospho-extracellular signal-regulated kinases (p-ERK), phospho-Akt (p-Akt), and p-P38 in SH-SY5Y cells. (a) SH-SY5Y cells were pretreated with 1 mM LiCl for 1 hr in the absence or presence of 100 nM E2 and then challenged with 20 μM 6-OHDA for 1 hr. Western blotting for p-ERK, p-Akt, and p-P38 of the control, 6-OHDA, 6-OHDA plus 1 mM LiCl, 6-OHDA plus 100 nM E2, 6-OHDA plus 1 mM LiCl and 100 nM E2, 100 nM E2 alone and 1 mM LiCl alone groups. (b) The quantification results of p-ERK, p-Akt, and p-P38 relative density are shown. The value corresponds to the mean ± SEM of three independent experiments that have been done in triplicate (n = 9). ∗p < 0.05 compared with the control group; #p < 0.05 compared with the 6-OHDA group. |