FIGURE

Figure 2

ID

ZDB-FIG-211025-116

Publication

Tanoue et al., 2021 - Podocyte-specific Crb2 knockout mice develop focal segmental glomerulosclerosis

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Figure 2

Podocyte-specific Crb2 knockout mice develop massive albuminuria and microhematuria at 2 months of age. (a) Massive albuminuria was observed at 2 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Microhematuria was observed at 2 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. (b) The blood urea nitrogen and serum creatinine levels were comparable among the three groups at 2 months of age. (c) The sclerotic indices were comparable among the three groups at 2 months of age. Scale bars 50 μm. (d) The fibrotic indices were comparable among the three groups at 2 months of age. Scale bars 100 μm. Data are presented as mean ± SD. Statistical analysis by one-way analysis of variance, followed by Scheffe's multiple comparison test; n = 6 in each group. **P < 0.01, ****P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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