ZFIN Image: Tanoue et al., 2021, Figure 2

Image

Figure Caption

Figure 2

Podocyte-specific Crb2 knockout mice develop massive albuminuria and microhematuria at 2 months of age. (a) Massive albuminuria was observed at 2 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Microhematuria was observed at 2 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. (b) The blood urea nitrogen and serum creatinine levels were comparable among the three groups at 2 months of age. (c) The sclerotic indices were comparable among the three groups at 2 months of age. Scale bars 50 μm. (d) The fibrotic indices were comparable among the three groups at 2 months of age. Scale bars 100 μm. Data are presented as mean ± SD. Statistical analysis by one-way analysis of variance, followed by Scheffe's multiple comparison test; n = 6 in each group. **P < 0.01, ****P < 0.0001.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.