FIGURE

Fig. 4

ID

ZDB-FIG-211009-15

Publication

Jang et al., 2021 - Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish

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Fig. 4

Functional validation of alx4a and gbx2 in iridophore development. a Lateral view of WT and alx1KO, alx3 KO, alx4b KO fish. b Lateral view of alx4a CRISPR-mediated knockout fish. c Iridophore detection in 4 dpf larvae of WT and alx4a knockout larvae. White arrows mark iridophores in WT larvae. d Lateral views of 1 dpf larvae, 2 dpf larvae, and adult fish comparing WT to Tg(miniCoopR-alx4a) and Tg(miniCoopR-gbx2) fish. e Representative pictures and quantification of iridophores from 3 dpf larvae tail trunks of WT (n = 21), Tg(miniCoopR-alx4a) (n = 20), and Tg(miniCoopR-gbx2) (n = 20). P values were calculated with two-tailed Welch’s t-test. Error bars represent ± SE. f Lateral whole-body view of iridophore rescue in three mosaic tg(miniCoopR-alx4a;alx4aKO) fish. Black box denotes the zoomed region in picture below

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	alx4a^j320/j320 alx4a^j321b/j321b alx4a^j322a/j322a alx4a^j322b/j322b alx4a^j323a/j323a alx4a^j323b/j323b alx4a^j324/j324 alx4a^j325a/j325a alx4a^j325b/j325b alx4a^j326a/j326a alx4a^j326b/j326b alx4b^j327/j327 j330Tg/j330Tg j331Tg/j331Tg alx4a^j321b/j321b; j330Tg/j330Tg
Observed In:	caudal fin iridophore iridophore melanocyte regulation of iridophore differentiation regulation of melanocyte differentiation
Stage Range:	Prim-5 to Adult

Phenotype Detail

Acknowledgments

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