FIGURE

Fig. 1

ID

ZDB-FIG-211009-13

Publication

Jang et al., 2021 - Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish

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Fig. 1

Epigenetic and transcriptomic dynamics of neural crest cell differentiation into pigment cells. a Schematic of sample collection method and principle component analysis on the DNA methylome, chromatin accessibility, and transcriptome of each cell type. b WashU Epigenome browser views of zebrafish early neural crest marker gene (sox9b), neural crest marker gene (twist1a), melanophore marker gene (tyr), and iridophore marker gene (pnp4a). Grey bars represent CpG sites while height of the blue bars indicates methylation levels. The red box demarcates promoter regions of marker genes. c–e Bar charts illustrating the number of DMRs (c), DEGs (d), and DARs (e) when comparing early NCCs, late NCCs, melanophores, and iridophores. DMRs were identified using DSS (p value < 0.001)

Expression Data

Gene:	EGFP
Fish:	j329Tg/j329Tg
Anatomical Terms:	iridophore melanocyte neural crest cell
Stage Range:	10-13 somites to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	j329Tg/j329Tg
Observed In:	iridophore chromatin binding iridophore methylated histone binding iridophore positive regulation of gene expression, epigenetic melanocyte chromatin binding melanocyte methylated histone binding melanocyte positive regulation of gene expression, epigenetic neural crest cell chromatin binding neural crest cell methylated histone binding neural crest cell positive regulation of gene expression, epigenetic
Stage Range:	10-13 somites to Day 5

Phenotype Detail

Acknowledgments

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