Figure 3
- ID
- ZDB-FIG-210925-37
- Publication
- Almeida et al., 2021 - Myelination induces axonal hotspots of synaptic vesicle fusion that promote sheath growth
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Myelination promotes vesicular fusion along reticulospinal axons (A and B) SypHy activity and myelination profile of reticulospinal axons in wild-type (WT) (A) and hypomyelinated (C) Myelin coverage in WT and (D and E) Axonal (D), but not collateral (E), SypHy frequency is decreased in (F and G) Amplitude (F) and duration (G) of SypHy events is similar in WT and (H) Myelination profile and SypHy activity of a Rohon-Beard axon. Kymograph of bracketed region. (I) Axonal SypHy frequency in rarely myelinated Rohon-Beard axons is significantly reduced compared to reticulospinal axons (p = 0.006 all RS versus Rohon-Beard, p > 0.05 unmyelinated. RS versus Rohon Beard, p = 0.001 myelinated. RS versus Rohon Beard; Kruskal-Wallis with Dunn’s multiple comparison test, 94 RS axons in 87 animals and 12 Rohon-Beard axons from 11 animals). Scale bars, 5 μm, 60 s (A, B, and H). Graphs display median and interquartile range. See also |