FIGURE

Fig 6

ID

ZDB-FIG-210912-6

Publication

Minenkova et al., 2021 - Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

Other Figures

All Figure Page

Back to All Figure Page

Fig 6

mtDNA amount is not significantly reduced in aldh7a1 knock-out zebrafish.

qPCR graph of mtDNA amount from wildtype (Wildtype, black circles) and aldh7a1 homozygous knock-out (aldh7a1 knock-out, grey squares) zebrafish embryos, demonstrating only a slight reduction in mtDNA copy number in knock-out relative to the wildtype embryos. Each dot represents DNA extracted from 5 embryos. The amounts of mtDNA from knock-out and wildtype embryos were normalized to the average mtDNA amount from the wildtype embryos. p value is calculated by an unpaired two-tailed student t-test. Error bars, mean and SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^{zf2074/zf2074}
Observed In:	whole organism mitochondrial chromosome
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One