FIGURE

Fig 5

ID

ZDB-FIG-210912-5

Publication

Minenkova et al., 2021 - Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

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Fig 5

A & B. Quantification of fold change in the electron transport chain enzyme activities in knock-out <italic toggle='yes'>aldh7a1</italic> 11 dpf embryos relative to the wildtype age-matched controls.

Electron transport chain enzyme activities are reduced in aldh7a1 knock-out zebrafish. 5A: individual and paired complexes and citrate synthase. 5B: ratio of individual and paired complexes to citrate synthase. Bar graph of the quantification of fold change in the electron transport chain enzyme activities in knock-out aldh7a1 11 dpf embryos (grey bars) relative to the wildtype age-matched controls (black bars). Each bar represents data collected from 300 embryos. The activity of each enzyme was measured in presumed homozygous 300 and 300 wildtype embryos. The values are depicted as enzyme activity in nmol/min/ mitochondrial protein mass normalized to the activity of citrate synthase (For further details please refer to Materials and Methods).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^{zf2074/zf2074}
Observed In:	whole organism citrate synthase activity whole organism cytochrome-c oxidase activity whole organism NADH dehydrogenase (ubiquinone) activity whole organism succinate dehydrogenase (quinone) activity
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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