FIGURE

Fig. 3

ID

ZDB-FIG-210912-3

Publication

Minenkova et al., 2021 - Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

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Fig. 3

Scatterplot of quantification of the levels of GABA metabolism pathway metabolites.

The levels of GABA metabolism reaction intermediates are reduced in aldh7a1 knock-out zebrafish embryos. It is shown in a scatterplot of quantification of the levels of GABA metabolism pathway metabolites, as measured by GC-MS and LC-MS/MS. The metabolite levels in 11 dpf aldh7a1 homozygous knock-out (aldh7a1 knock-out, grey squares) embryos are significantly decreased relative to the wildtype (Wildtype, black circles). Each dot represents metabolite data collected from 20 embryos. p values were calculated by unpaired student t-test for multiple measurements followed by Holm-Sadak correction for multiple analysis. Error bars, SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	aldh7a1^{zf2074/zf2074}
Observed In:	whole organism 4-hydroxybutyrate whole organism gamma-aminobutyric acid whole organism glutamate(1-) whole organism glutamine whole organism succinic semialdehyde
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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