Image
|
Figure Caption
Figure 3
atRAL-induced ER stress was attenuated by pregabalin. Cells were dosed with 50 µM atRAL, 1 mM pregabalin (PGB), or both for 24 h. RT-qPCR was performed analysing the expres-sion of ER stress markers. Dosing with atRAL significantly increased expression of sXBP1 (A′, B′, C′), ATF4 (A″, B″, C″), and CHOP (A‴, B‴, C‴) in p.Y226C (A), p.A109P (B), and p.S13 (C) cell lines. Dosing with pregabalin reduced expression of ER stress markers. Statistical significance was analysed using one-way ANOVA and Sidak’s multiple comparison test. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Int. J. Mol. Sci.