Fig. 8

STIM1-protein expression in human normal and thyroid cancer tissues. A, B Representative images of normal and papillary thyroid cancer. C, D Representative images of normal and follicular thyroid cancer tissue. E, F Representative images of normal and anaplastic thyroid cancer tissue. The representative images of control and cancer tissue sections of each cancer type are from the same patient. G Representative image of normal thyroid tissue from a healthy subject. Scale bar 50 µM. The final images were acquired at 20× magnification using case viewer software (3DHITECH Ltd, Germany). H Heatmap to visualize differential expression of STIM1 and ORAI1 between thyroid tumors and their adjacent normal samples. The color intensity represents log2 Fold Changes. Significances have been corrected by Benjamini–Hochberg method. *p < 0.05; **p < 0.01; ***p < 0 .001. I STIM1 expression comparison between thyroid cancer tissues, their para-cancerous tissues, and normal controls. Data were presented as mean ± SE. One-way ANOVA test was used to assess statistical significance. ***p < 0 001. J STIM1 and ORAI1 expression comparison between papillary thyroid cancer tissues and follicular thyroid cancer tissues. Data were presented as mean ± SE. Unpaired t test was used to assess statistical significance. **p < 0.01.