FIGURE

FIGURE 2

ID

ZDB-FIG-210807-2

Publication

Li et al., 2021 - An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease

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FIGURE 2

ACT regulated M1/M2 polarization in LPS-stimulated BV-2 cells. (A) Effects of ACT on LPS-induced BV-2 cell viability. (B) Cell morphology with IBA-1 staining was observed with inverted phase contrast fluorescence microscope (×10). The control group exhibited small soma with distal arborization, showing the typical ramified morphology of resting microglia. The LPS group became fewer and shorter branches with a greatly enlarged cell body, the characteristic shapes of activated microglia. The ACT groups showed attenuated LPS-induced morphological changes. (C) Effects of ACT on LPS-induced elevation of cell supernatant TNF-α, IL-1β, and IL-10 levels as well as NO elevation. *P < 0.05, ***P < 0.005, versus the LPS group. n = 3. Berberine (BBR) as a positive control. (D) Effects of ACT on M1 microglia polarization related markers. (E) Effect of ACT on M2 microglia polarization related markers. *P < 0.05, **P < 0.01, ***P < 0.005, versus the LPS group. n = 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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