FIGURE

FIGURE 5

ID

ZDB-FIG-210807-5

Publication

Li et al., 2021 - An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer's Disease

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FIGURE 5

ACT bond to and inhibited NF-κB as well as activated AMPKα. (A) ACT distinctly increases the phosphorylation level of AMPKα. (B) The effect of compound C (1 μM) on NO level. ***P < 0.001, versus the LPS group. ##P < 0.01, versus the LPS+ACT group. n = 3. (C) A three-dimensional visual of the binding sites between ACT and NF-κB. (D) A two-dimensional close-up of the molecule binding pocket from the side. (E) Amino acid residues. (F) A three-dimensional visual of the binding sites between ACT and AMPKα. (G) A two-dimensional close-up of the molecule binding pocket from the side. (H) Amino acid residues.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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