FIGURE

Fig. 8

ID

ZDB-FIG-210804-21

Publication

Fang et al., 2021 - Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

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Fig. 8

Schematic diagram of Asxl1 mutations resulting in myeloid malignancies in zebrafish.

In our model, C-terminally truncated with asxl1 mutations specifically blocked neutrophil differentiation. The mutants initially exhibited an MDS-like phenotype with neutrophilic dysplasia, and some mutants progressed to more severe phenotypes, similar to CMML/AML disease. Dysregulation of bmi1a may be a reason for leukemogenesis in asxl1 mutants. Asxl1 wild-type Asxl1 protein, tAsxl1 truncated Asxl1 protein.

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Acknowledgments

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