FIGURE

Fig. 7

ID

ZDB-FIG-210712-8

Publication

Butti et al., 2021 - Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Sv2a interacts with C9orf72 and its protein expression is downregulated in C9-miR fish.

a Volcano plot showing the log2 fold change against the −log10 p value. Proteins in blue are upregulated while proteins in red are downregulated (log2 fold change of −1.5 and 1.5, delineated by vertical lines) and are significantly dysregulated (−log10 (p value) > 1.301, delineated by horizontal dotted line) between control and C9-miR fish (N = 4). b Differentially expressed proteins with p < 0.05 in C9-miR 6 dpf larvae (N = 4). c Immunoblot analysis of RFP-immunoprecipitated proteins and lysate of HEK293T cells co-expressing RFP-tagged C9orf72 or RFP in combination with Myc-tagged SV2a or Myc-tagged SMRC8 (a known interactor of C9orf72; positive control). Myc-SV2a and Myc-SMCR8 were extracted out of solution in samples where RFP-C9orf72 was co-transfected, but not in samples where RFP was co-transfected (N = 3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Commun Biol