Fig. 4
a SD-OCT shows a significant increase in axial length in 6?mpf gjd2b (Cx35.1) mutants (n?=?24 eyes). b Loss of lenticular projection intensity of isolated mutant lenses (n?=?24 eyes), the following wavelengths were used: IR light (940?nm), UV light (365?nm), and broad-spectrum visible light (380?760?nm). c Schematic illustration of the ex vivo lenticular light propagation setup. d Examples of light propagation in three isolated 6?mpf WT control lenses. e?g Examples of light scattering and multifocality by two moderately cataractous lenses (e) and (f) and light diffusion by a severely cataractous lens (g) of the 6?mpf gjd2b (Cx35.1) mutant. Error bars: SEM. Significance: ns?=?not significant, *p?0.05, **p?0.01, ***p?0.001. IR infrared, UV ultraviolet. |