FIGURE

Fig. 6

ID

ZDB-FIG-210606-19

Publication

Wong et al., 2021 - Mvda is required for zebrafish early development

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Fig. 6

Morpholino knockdown of mvda induces potent apoptosis in heart and eyes. Control-MO-injected embryos and embryos injected with mvda-e3i3-MO were stained with acridine orange at 4-dpf. Apoptotic cells are visible as bright green spots, and less bright homogenous green staining is unspecific background staining. A, C Control-MO-injected zebrafish exhibited few or no apoptotic cells in heart and eyes. B, D In contrast, significantly increased staining was observed throughout the heart and eyes in zebrafish injected with mvda-e3i3-MO (circled areas and red arrow). E Quantification of apoptosis particle number at heart shows a 15.8-fold increase in mvda morphants. F Quantification of apoptosis particle number at eyes shows a 24-fold increase in mvda morphants. Error bars, s.e.m.; ***P < 0.0001(n = 10; Student’s t test); A–D: lateral view, anterior, left. dpf days post fertilization. Scale bars = 100 µm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mvda
Knockdown Reagent:	MO1-mvda
Observed In:	eye apoptotic process heart apoptotic process
Stage:	Day 4

Phenotype Detail

Acknowledgments

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