FIGURE

FIGURE 6

ID

ZDB-FIG-210601-19

Publication

Wang et al., 2021 - Potential of peptide-engineered exosomes with overexpressed miR-92b-3p in anti-angiogenic therapy of ovarian cancer

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FIGURE 6

Engineered RGD‐SKOV3‐92b/exo alone or combined with Apatinib inhibits tumor growth in vivo. (A) Representative confocal microscopy images of HUVECs treated with SKOV‐92b/exo or RGD‐SKOV3‐92b/exo. F‐actin (red), nucleus (blue), and PKH67‐labeled exosomes (green) were stained (scale bar = 30 μm). Relative uptake was calculated using ImageJ software. (B) Total fluorescence values of nude mice in different groups. There were no differences among randomization groups for any of the characteristics. (C) Schematic protocol of intraperitoneal xenografted tumors in animal experiments. (D) Bioluminescence images of nude mice with different exosomal injections or Apatinib treatment. Total fluorescence values were assessed by fluorescence imaging (n = 5 per group). Data are shown by at least three independent experiments. The Student's t‐test and nonparametric test were used to compare differences. *p < .05, **p < .01, ***p < .001, ****p < .0001

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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