FIGURE

FIGURE 5

ID

ZDB-FIG-210520-26

Publication

Zhao et al., 2021 - Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

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FIGURE 5

Crocetin and crocin inhibited endothelial cell migration and capillary-like tube formation. (A) Wound healing assay for HUVEC migration after 20 h of incubation with vehicle control or drug treatments. (B) The migratory ability was evaluated by measuring the mean length of the scraped area of each well and comparing it to the control group. Yellow dashed lines indicated the wound edges. (C) Morphological features of the capillary-like tube formation of HUVECs in Matrigel after 6 h of incubation with vehicle control or drug treatments. (D) The tube formation ability was evaluated by measuring the total tube length of HUVECs and comparing it to the control group. Scale bar = 200 μm. Data are means ± SD of three independent experiments. Statistical analysis was performed by one-way ANOVA followed by Dunnett's test. *p<0.05 and ***p<0.001 versus control group.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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