FIGURE

FIGURE 2

ID

ZDB-FIG-210520-23

Publication

Zhao et al., 2021 - Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

Other Figures

All Figure Page

Back to All Figure Page

FIGURE 2

Crocetin and crocin inhibited SIV formation in Tg(fli1:EGFP) zebrafish embryos. Zebrafish embryos at 24 hpf were treated by (A,A’) 0.1% DMSO (Control) (E,E’) 50 ng/ml VRI, (B-D,B’-D’) crocetin, or (F–I,F’–I’) crocin for 48 h. (A’–I’) Magnified views (100× magnification) of the panels labelled A to I (40× magnification). Mature SIVs are indicated by white arrows. Moderately defective SIVs are indicated with yellow arrows and severely defective SIVs are indicated with red arrows (J and K) Quantification of the total area of SIVs reduced by crocetin and crocin. Data are percentages of the control, measured as means ± SD (10 zebrafish embryos per well from three time-independent experiments, n = 3). Scale bar = 200 μm. Statistical analysis was performed by one-way ANOVA followed by the Dunnett’s test. *p<0.05 and ***p<0.001 versus control group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol